Behaviour 2019
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Effects of maternal exposure to bisphenol-S on zebrafish offspring’s anxiety and social behaviour
Arash Salahinejad, Anoosha Attaran, Som Niyogi, Douglas Chivers. University of Saskatchewan, Saskatoon, Saskatchewan (SK), Canada

Bisphenol S (BPS) is one of the main substitutes of bisphenol A that is increasingly used in a wide range of industrial and consumer products. Recent studies show that BPS induces multiple adverse effects; however, the transgenerational impacts of BPS remain largely unknown. In the present study, adult female zebrafish (Danio rerio) were exposed to environmentally relevant concentrations of BPS (0, 1, 10, 30 g/L) and 1 g/L of 17-β-estradiol (E2) as a positive control for a period of 60 days. Female fish have then paired with control male zebrafish and their offsprings were collected and raised in control water for 6 months. Our results indicated that maternal exposure to BPS influences anxiety and social responses of offspring in a dose-specific manner. Specifically, 1, 30 g/L BPS and 1 g/L E2 induced anxiolytic effects and 1 g/L BPS disrupted group preferences in F1 generation. The impaired anxiety and shoaling responses were associated with dysregulations in the transcription of genes involved in enzymatic antioxidant defense and the neuropeptide signaling system (arginine vasotocin and isotocin).