Behaviour 2019
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HDAC6 inhibitor Tubastatin A induces inhibitory avoidance memory facilitation in mice
Sebastián Rivas1,3, Laura Esquivel1, Ángeles Salles1, Julia Busso1, Julieta Millán2, María Krawczyk2,3, Mariano Boccia2,3, Ramiro Freudenthal1,3. 1Neuronal plasticity and memory lab - iB3 - UBA, Buenos Aires, Outside US/Canada, Argentina; 2Neuropharmacology of memory processes lab - UBA, Buenos Aires, Outside US/Canada, Argentina; 3CONICET, Buenos Aires, Outside US/Canada, Argentina

Memory formation is a complex event which involves several internal changes that are manifested behaviorally. Post translational modifications of proteins, such as acetylation, are some of these processes. We performed a one trial inhibitory avoidance task in mice to evaluate the effect of histone deacetylase inhibitors on memory formation.
We found that the HDAC6 inhibitor Tubastatin A has a memory facilitator effect on the inhibitory avoidance memory. This inhibitor seems to be acting at the consolidation phase of the mentioned memory given that the effect is evident when the drug is administered immediately after inhibitory avoidance task is perform but not when administered 3 hours later. Finally, the observed effect of HDAC6 inhibitor on memory is different of others HDACs inhibitors such as sodium butyrate. These results suggest a role for cytoplasmic protein acetylation in memory consolidation.