Presentation Details
| Insights From a Multi-Year Study of a Population of Free-Living, Isogenic Mice Matthew N Zipple, Michael J Sheehan. Cornell University, LASER Lab, Ithaca, NY, USA |
Abstract
Genetically uniform mice have long been the go-to biomedical model vertebrate, allowing causal conclusions about how experimental treatments shape individual outcomes. But despite decades of study, the extent to which ecologically relevant environmental variation shapes individual behavior and development remains essentially unknown, due to the artificial and constant environments in which isogenic mice are typically studied. Here we report results from an ongoing multi-year study of a population of freely living, isogenic mice living outdoors in an ecologically realistic environment. We document strong seasonal effects on daily movement and circadian patterns in these animals as well as seasonal effects on social structure and behavioral development. These results add to a growing body of evidence that the behaviors and physiology of mice living within a laboratory environment bear only a limited resemblance to genetically identical animals living under complex, ecologically relevant conditions.
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No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author.
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